What to Do If Your Patient Misses an INVEGA TRINZA® Dose
Time since last injection1
- Early or late by 2 weeks: Patients may be given the injection ±2 weeks from their scheduled 3-month dose
- Longer than 3½ months, but less than 4 months: Previous dose should be administered as soon as possible, then continue with 3-month injections
- 4 months up to and including 9 months: Do not administer the next dose, but use the reinitiation table below
- Longer than 9 months: Reinitiate treatment with INVEGA SUSTENNA® (paliperidone palmitate) per its prescribing information. INVEGA TRINZA® can be resumed after >4 monthly INVEGA SUSTENNA® treatments
Arrows illustrate reinitiation regimen of INVEGA SUSTENNA® after missing 4 months to 9 months of INVEGA TRINZA®.
Missing antipsychotic doses should be avoided.1
Switching Back to INVEGA SUSTENNA®, If Needed
When switching patients from INVEGA TRINZA® back to INVEGA SUSTENNA®, INVEGA SUSTENNA® should be administered at the time of the next INVEGA TRINZA® dose using the equivalent 3.5-fold lower dose as shown in this table.1
INVEGA SUSTENNA® should then continue to be dosed at monthly intervals.1
Arrows illustrate the corresponding dose conversion from INVEGA TRINZA® to INVEGA SUSTENNA®.
*The initiation dosing as described in the prescribing information for INVEGA SUSTENNA® is not required.
Switching to Paliperidone Extended-Release Tablets, If Needed
When switching from INVEGA TRINZA® to paliperidone extended-release tablets (INVEGA®), the daily dose of paliperidone extended-release tablets should be started 3 months after the last INVEGA TRINZA® dose and administered over the next several months after the last INVEGA TRINZA® dose as shown in this table.1
Arrows illustrate the corresponding dose conversion from INVEGA TRINZA® to paliperidone extended-release tablets.
Reference: 1. INVEGA TRINZA® [prescribing information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.; February 2017.